Antigenics vaccine promising in small cancer study

By Toni Clarke

BOSTON (Reuters) - Biotechnology company Antigenics Inc said on Monday that its Oncophage vaccine extended survival in a small study of patients with brain cancer.

Results from the 12-patient study, which were presented at the annual meeting of the Society for Neuro-Oncology in Las Vegas, showed that patients who were vaccinated with Oncophage following brain cancer surgery lived on average for 10.5 months.

This compares with a historical median survival post-surgery of 6.5 months. All patients enrolled in the trial had received surgery, followed by chemotherapy and radiation, and had seen their cancer recur.

Four patients in the study lived for about 12 months, one lived for 2.5 years. The least successful patient lived four months.

In 2006, Oncophage failed to meet the main goal of a kidney cancer trial, making its approval in the United States unlikely. It has also failed a trial to treat skin cancer.

However, it was approved earlier this year in Russia to treat a subset of kidney cancer patients whose cancer has been fully removed following surgery and has not spread to other parts of the body.

Oncophage is designed to reprogram the body’s immune system to target only cancer cells bearing the fingerprint of the patient’s particular cancer, leaving healthy tissue intact.

Trials of only 12 people typically have limited significance as the results could be due to chance.

But Dr. Andrew Parsa, the lead investigator on the trial — who receives no compensation from Antigenics — said the reason the results are interesting is that they correlate to a patient-specific, measurable immune response.

In other words, the clinical response was related to a visible change in the patients’ immune system.

“This study demonstrated significant tumor-specific immune responses leading to a proliferation of T-cells which did not exist in these patients before vaccination,” said Parsa, who is associate professor at the University of California, San Francisco. “We look forward to completing the Phase II portion of this study and presenting results next year.”

Results from this trial have been reviewed by the National Cancer Institute, which plans to sponsor two new trials of the vaccine in brain cancer: one in children, and the other in adults.

About 19,000 cases of glioma, the most common type of brain cancer, are diagnosed each year in the United States, according to the National Cancer Institute.

(Reporting by Toni Clarke, editing by Matthew Lewis)

Source

--------------------------------------------------------------------------------------------
Related Posts:


CHICAGO (Reuters) - A long-term study of brain scans in multiple sclerosis patients showed only about half of the patients who took the drug interferon beta 1-b got a long-lasting benefit, U.S. researchers said on Monday. Patients in the small, three-year study were treated with the Bayer drug, which is sold under the trade name Betaseron

Full Post: Bayer drug delays MS in half of patients: MRI study
--------------------------------------------------------------------------------------------

By Maggie Fox, Health and Science Editor WASHINGTON (Reuters) - Combining two chemotherapy drugs with two targeted therapies was safe and appeared to help patients with advanced lung cancer live longer, U.S. researchers reported on Thursday. The combination of Roche and Co’s Avastin, ImClone’s Erbitux, carboplatin and paclitaxel appeared to add an average of two months to

Full Post: Four drug combination helps in lung cancer: U.S. study
--------------------------------------------------------------------------------------------

LOS ANGELES (Reuters) - A combination of Genentech Inc’s cancer drug Rituxan and chemotherapy reduces by 41 percent the risk of death or cancer progression, compared with chemotherapy alone, for patients with a common form of leukemia, the company said on Saturday. Results from the pivotal- or final-stage trial found that previously untreated patients given the

Full Post: Genentech drug boosts leukemia patient survival
--------------------------------------------------------------------------------------------

By Deena Beasley LOS ANGELES (Reuters) - Patients treated with GlaxoSmithKline PLC’s Promacta rather than a placebo were eight times more likely to have sustained increases in platelet counts, according to pivotal trial results announced by the company on Saturday. Promacta, also known as eltrombopag, was approved by the U.S. Food and Drug Administration last month for

Full Post: Glaxo says oral drug raises blood platelet counts
--------------------------------------------------------------------------------------------

By Maggie Fox, Health and Science Editor WASHINGTON (Reuters) - The lung cancer pill Iressa has shown surprising results for patients with advanced disease where it has been at least as effective as a standard chemotherapy treatment, researchers reported on Thursday. Patients who got the once-a-day pill made by AstraZeneca lived as long as those given the

Full Post: Lung cancer pill may get second chance after tests

Site Navigation

Most Read

Search