When kids wheeze, steroids don’t help: studies

By Gene Emery

BOSTON (Reuters) - Giving steroids to children who are wheezing because of viral or other infections does not help, researchers reported on Wednesday.

And an experimental treatment designed to prevent wheezing may be effective, but it seems to pose too many risks to be recommended, according to studies published in the New England Journal of Medicine.

About one-third of preschool children develop wheezing, which can worry parents. At least 75 percent outgrow the problem by age 6. In the past, doctors have treated it as they would asthma, which is why they often use corticosteroids.

“It is clear that on the basis of these two studies, current practice must change,” Dr. Andrew Bush of the Imperial School of Medicine and Royal Brompton Hospital in London wrote in a commentary.

Dr. Jonathan Grigg of Queen Mary University in London and colleagues found that children given five days of the steroid prednisolone stayed just as long in hospital as children given a placebo. They tested nearly 700 children aged 10 months to 5 years old.

Nor was there any difference in their symptoms over the next seven days, Grigg’s team reported.

“If your child is very sick, it doesn’t mean you shouldn’t give oral steroids. But in the general run of things, for most kids at home or presenting to their doctor with moderate wheezing that doesn’t require many days in the hospital, steroids are not going to be of any benefit,” Grigg said in a telephone interview.

“I would have loved for steroids to work,” Grigg added.

However, he said, the result “does fit into the general perception that preschool wheeze is very different from attacks of allergic asthma in older children and adults.”

UNNECESSARY TREATMENT

Bush wrote: “It is disturbing to contemplate how many unnecessary courses of prednisolone have been given over the years, in good faith, because we all assumed that preschool children are little adults. There is certainly a lesson there for the use of other medications.”

The second study compared GlaxoSmithKline’s Flovent, available generically as fluticasone, with a placebo in 129 children aged 1 to 6 years. At the first sign of nasal congestion, sore throat or other symptoms that might indicate an upper respiratory tract infection, the children were treated twice daily for up to 10 days.

The drug seemed to help, Dr. Francine Ducharme of the Center Hospitalier Universitaire in Montreal and colleagues reported.

While 18 percent of the youngsters in the placebo group needed further treatment with steroid drugs, the rate was 8 percent for those who got Flovent.

But the children who got Flovent tended to grow less — a tenth of an inch (one-third of a centimeter) less over nearly 10 months — than those getting placebo.  Continued…

Source

--------------------------------------------------------------------------------------------
Related Posts:


By Will Dunham WASHINGTON (Reuters) - People with the lung ailment chronic obstructive pulmonary disease are more likely to get pneumonia if they use inhaled corticosteroid drugs and doctors should be more cautious in prescribing them, researchers said. People with smoking-related chronic obstructive pulmonary disease, or COPD, who took the drugs for symptoms such as cough, wheezing,

Full Post: Inhaled steroids up pneumonia risk in lung ailment
--------------------------------------------------------------------------------------------

WASHINGTON (Reuters) - A usually harmless childhood virus may hide in the lungs and come back to cause wheezing and other symptoms of asthma, U.S. researchers reported on Tuesday. They found evidence that respiratory syncytial virus or RSV stayed in the lungs of mice and caused the overactive airway symptoms that characterize asthma. “This research suggests that

Full Post: “Harmless” virus may hide and cause asthma
--------------------------------------------------------------------------------------------

LONDON (Reuters) - Antipsychotic drugs prescribed to treat aggression in older Alzheimer’s patients appear to significantly raise their risk of dying prematurely, British researchers said Friday. The results from the first long-term study on the effect of the medicines on people with Alzheimer’s highlights the need to seek less harmful treatments for many of these patients,

Full Post: Antipsychotics for Alzheimer’s up death risk: study
--------------------------------------------------------------------------------------------

LONDON (Reuters) - Babies born by Caesarean section are more likely to develop asthma than children delivered naturally, Swiss researchers said on Tuesday. There has been conflicting evidence on the link between asthma and C-sections but the researchers said the number of children involved in their study and a long monitoring period strengthened their results. The findings

Full Post: Researchers link C-section babies to asthma risk
--------------------------------------------------------------------------------------------

NEW YORK (Reuters Health) - People with severe asthma who are allergic to fungal organisms benefit substantially from treatment with the anti-fungal drug itraconazole, new research shows. To check out this strategy, a trial was conducted in the UK involving patients who needed high doses of steroids to control their asthma and who were sensitive to

Full Post: Antifungal treatment helps some asthma patients

Site Navigation

Most Read

Search