Obesity pill shows promise: study

By Michael Kahn

LONDON (Reuters) - People taking NeuroSearch A/S’s obesity pill tesofensine lost twice as much weight as men and women using approved weight loss drugs, Danish researchers said on Thursday.

The study suggest the experimental drug is safe because it had no effect on blood pressure and only raised heart rate slightly, said Arne Astrup of the University of Copenhagen, who led the study published in the journal Lancet.

“It is quite solid from this study that it seems to produce a weight loss that is twice … what we see from existing compounds on the market,” Astrup said in a telephone interview.

The company hopes to take tesofensine to Phase III clinical trials early next year — the last stage of human testing before a company can seek regulatory approval for a drug.

Obesity, which raises the risk of diseases like type 2 diabetes and heart problems, is increasingly a problem as more people adopt a Western lifestyle.

The World Health Organization classifies around 400 million people around the world as obese, representing an increasingly lucrative market for drug makers.

Astrup and his team compared tesofensine against the Sanofi-Aventis SA obesity-fighting drug Acomplia and Abbott Laboratories’ Reductil, known as Meridia in the United States.

The 203 obese volunteers at five Danish obesity centers were given different doses of tesofensine or placebo. The drug worked twice as well as previously published data on Acomplia and Reductil, known generically as sibutramine, the study showed.  Continued…


Related Posts:

LONDON (Reuters) - Phone and email counseling help people improve their diet and lose weight, according to a Dutch study published on Friday that points to a potentially simple but effective tool in the fight against obesity. The study of 1,400 Dutch overweight workers suggests this kind of lifestyle advice is especially good for people unwilling

Full Post: Weight loss a phone call away, study finds

NEW YORK (Reuters Health) - Obesity appears to increase the risk of miscarriage, according to a review study appearing in the journal Fertility and Sterility. “Obesity has been described as the new worldwide epidemic, and as the (rate) of obesity increases, so does the number of women of reproductive age who are becoming overweight and obese,”

Full Post: Obesity increases risk of miscarriage

NEW YORK (Reuters Health) - Efforts to fight obesity among children and teens should include strategies to help them think differently about their eating and exercise habits, researchers conclude based on a review of 64 studies of lifestyle “therapy” and drug interventions. And it’s important for parents to get involved, especially for pre-adolescent children, Dr. Hiltje

Full Post: Lifestyle changes benefit overweight kids

By Megan Rauscher NEW YORK (Reuters Health) - Obesity surgery, also known as bariatric surgery, not only helps obese individuals shed a significant amount of weight, it also significantly improves or completely resolves a common obesity-related liver problem known as non-alcoholic fatty liver disease, a review of published studies shows. So-called “non-alcoholic fatty liver disease” is an

Full Post: Liver disease may resolve with weight loss surgery

By Will Boggs, MD NEW YORK (Reuters Health) - Sexual dysfunction that commonly occurs in morbidly obese men improves after weight loss surgery, according to a new study. “Sexual dysfunction should be considered one of the numerous potentially reversible complications of obesity,” the study team concludes. Dr. Ramsey M. Dallal, from Albert Einstein Healthcare Network, Philadelphia, and colleagues

Full Post: Weight loss surgery improves sexual function in men

Site Navigation

Most Read



  • kinwrite.com@gmail.com