Partial vaccine dose may work as well as full shot

LONDON (Reuters) - Giving just one fifth the dose of a commonly used meningitis vaccine may be as effective as using the full dose, researchers said on Tuesday.

The finding should allow medics to stretch scarce vaccine resources, especially during epidemics in Africa.

A clinical study conducted in Uganda by Epicentre — the research arm of medical charity Medecins Sans Frontieres — found similar immune responses in patients given low and full doses of Sanofi-Aventis’s vaccine Menomune.

Serum bactericidal activity (SBA) response with a one-fifth dose was comparable to full dose for three bacteria types targeted by the vaccine, though not a fourth.

Although another measure of immune response, IgG level, was lower for fractional doses, the researchers said short-term protection needed during mass vaccination programs was best measured by SBA.

“In view of the current shortage of meningococcal vaccines for Africa, the use of one-fifth fractional doses should be considered as an alternative in mass vaccination campaigns,” the research team reported in the journal PLoS Neglected Tropical Diseases.

Meningitis epidemics occur nearly every year across a large part of sub-Saharan Africa spanning Senegal to Ethiopia, dubbed the “Meningitis Belt.”

Meningitis infects the lining of the brain and spinal cord and can cause high fever, blood poisoning and brain damage, as well as death in up to 10 percent of cases.

The full report on the study is available online here

(Reporting by Ben Hirschler; Editing by Andrew Macdonald)


Related Posts:

By Will Dunham WASHINGTON (Reuters) - A half dose of flu vaccine may work just as well as the full dose for healthy adults under 50 — a finding that could help stretch supplies in the event of a future vaccine shortage, researchers said on Monday. The study involved about 1,100 U.S. adults, about half of whom

Full Post: Flu shot half dose just as good for younger adults

By Will Dunham WASHINGTON (Reuters) - U.S. health officials asked doctors on Thursday to be alert for possible cases of meningitis and other illnesses in children caused by Hib bacteria amid an ongoing vaccine shortage. Officials are most concerned about bacterial meningitis and sepsis, a bloodstream infection, caused by Hib (Haemophilus influenzae type b) in children under

Full Post: Doctors to be on guard for meningitis in kids

NEW YORK (Reuters Health) - Hepatitis A infections, usually transmitted via contaminated food, can cause debilitating illness, but protection afforded by the hepatitis A vaccine last more than a decade, a new study shows. In fact, antibodies against hepatitis A virus persist for up to 27 years after vaccination, report investigators from the Centers for Disease

Full Post: Hepatitis A vaccine gives long-lasting protection

By Maggie Fox, Health and Science Editor WASHINGTON (Reuters) - An experimental malaria vaccine is the most promising yet, protecting up to 65 percent of infants from infection in two studies in Africa, researchers reported on Monday. Separate tests in Kenya and Tanzania showed GlaxoSmithKline’s vaccine called RTS,S could protect babies and toddlers from infection with malaria

Full Post: Glaxo malaria vaccine protects babies, children

By Will Boggs, MD NEW YORK (Reuters Health) - Protection against hepatitis B appears to drop off in adolescents who got the hepatitis B vaccine beginning at birth, according to a new report. Dr. Stephanie R. Bialek from the US Centers for Disease Control and Prevention, Atlanta, Georgia, and colleagues evaluated the occurrence of breakthrough infections and

Full Post: Hepatitis B vaccine protection may wane in teens

Site Navigation

Most Read