Resveratrol may treat alcoholic liver disease

NEW YORK (Reuters Health) - Resveratrol, an antioxidant abundant in grapes, red wine, peanuts — and, according to a new study, dark chocolate and cocoa — may prevent and treat the build-up of fat in the liver caused by chronic alcohol drinking.

In experiments with mice, resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and increased the rate at which liver fat was broken down.

Chronic heavy alcohol drinking causes fat to accumulate in the liver and can lead to cirrhosis, fibrosis, and other liver diseases. “Our study suggests that resveratrol may serve as a promising agent for preventing or treating human alcoholic fatty liver disease,” the researchers conclude in a report in the American Journal of Physiology–Gastrointestinal and Live Physiology.

Previous work has shown that chronic alcohol ingestion inhibits two proteins — AMPK and SIRT1 — that play a key role in the breakdown of fats in the liver. When alcohol inhibits these two proteins, it allows fat to accumulate.

By activating AMPK and SIRT1, resveratrol helps to clear fat from the liver, the new study indicates.

In the study, mice were maintained on a low-fat diet and some were fed resveratrol alone, alcohol alone, or the combination of resveratrol plus alcohol.

Tests on the animals showed that resveratrol treatment boosted levels of SIRT1 and stimulated the activity of AMPK in the livers of mice fed alcohol. Increased expression and activity of SIRT1 and AMPK also fueled a reduction in the levels and activity of other liver proteins involved in fat buildup and boosted levels of the fat metabolizing hormone adiponectin.

Taken together, these results indicate that resveratrol prevents alcoholic fatty liver disease by coordinating molecules that control fat metabolism.

In a separate study published this month, researchers report that cocoa powder, baking chocolate and dark chocolate all contain significant levels of resveratrol.  Continued…


Related Posts:

By Megan Rauscher NEW YORK (Reuters Health) - Obesity surgery, also known as bariatric surgery, not only helps obese individuals shed a significant amount of weight, it also significantly improves or completely resolves a common obesity-related liver problem known as non-alcoholic fatty liver disease, a review of published studies shows. So-called “non-alcoholic fatty liver disease” is an

Full Post: Liver disease may resolve with weight loss surgery

By Will Dunham WASHINGTON (Reuters) - Women who consume more than two alcoholic drinks a day have a higher risk of getting the most common type of heart rhythm disturbance, which can raise the chances of having a stroke, researchers said on Tuesday. Previous research had shown that men who drink three or more alcoholic beverages daily

Full Post: Heart rhythm risk seen in women’s alcohol drinking

NEW YORK (Reuters Health) - A glass or two of wine per day may increase the amount of heart-healthy omega-3 fatty acids in a person’s blood, a new study suggests. The study of European adults found that those who drank in moderation tended to have higher blood levels of omega-3 — even when intake of fish,

Full Post: A little wine may boost heart-healthy omega-3

NEW YORK (Reuters Health) - New research indicates that most children who are 5-year survivors of liver transplantation have good graft function; however, chronic medical conditions and complications affecting other organs are common in this patient population. “The success of liver transplantation in children is defined by more than just excellent survival rates. Better understanding of

Full Post: Children do well 5 years after liver transplant

NEW YORK (Reuters Health) - There is no link between drinking alcohol and the likelihood of worsening chronic obstructive pulmonary disease, or COPD, according to a study of patients seen at Veteran Affairs hospitals. COPD includes conditions such as emphysema and chronic bronchitis. “While tobacco consumption has a well-established role in COPD-related morbidity, relatively less is

Full Post: Alcohol doesn’t worsen chronic lung conditions

Site Navigation

Most Read