Uncorrected heart defect ups risk of infant death

NEW YORK (Reuters Health) - Infants born with a congenital heart defect that goes uncorrected have a much greater risk of dying than their counterparts who have the heart defect corrected, suggest results of a new study.

The birth heart defect known as patent ductus arteriosus, or PDA, afflicts mainly infants who are born very prematurely. The defect occurs when a large blood vessel near the heart — the ductus arteriosus — fails to close at birth. The condition leads to abnormal blood flow between the aorta and pulmonary artery, two major blood vessels surrounding the heart.

Because the standard of care has been to attempt to close the PDA in preterm infants, there is little information on the outcome of infants with a persistently open ductus arteriosus.

Dr. Shahab Noori from University of Oklahoma, Oklahoma City and colleagues examined the possible impact of the failure to close the PDA on death in 301 infants who were born prematurely weighing 1500 grams or less.

“Basically what we found was that preterm infants whose ductus arteriosus failed to close either spontaneously or with medication had an eight-fold increase in risk of dying during the initial hospital stay,” Noori told Reuters Health.

In the January 2009 issue of Pediatrics, the investigators point out that the 41 infants with a persistently open ductus arteriosus had lower birth weight and were less mature than the 260 infants with a closed ductus arteriosus.

According to the clinicians, the “unadjusted” death rate was 70 percent in infants with an open ductus arteriosus versus 11 percent in those with a closed ductus arteriosus.

“The increased odds of mortality was noted even when known risk factor for death such as degree of prematurity and infection were taken into account,” Noori said.

“Although our study does not establish the patent ductus arteriosus as the cause of increased mortality, it strongly raises this possibility,” Noori concluded.

SOURCE: Pediatrics, January 2009.


Related Posts:

NEW YORK (Reuters Health) - Results of a Swedish population-wide study hint that children born prematurely have some risk of developing anxiety, depression or other psychiatric disorder in adolescence and young adulthood. Children born “preterm” should therefore be watched more closely for these disorders, the investigators suggest. Among 545,628 Swedish residents born in the 1970s and followed

Full Post: Preemies face some risk of psychiatric disorders

NEW YORK (Reuters Health) - Infants born prematurely at very low birth weights who are fed a special enriched formula, rather than standard formula, show better growth and bone mineral content during the first 2 months after hospital discharge, according to a study from France. The beneficial effects demonstrated in the present study and previous studies

Full Post: Enriched formula has lasting benefits for preemies

By Karla Gale NEW YORK (Reuters Health) - The incidence of reddish skin tumors called infantile hemangiomas has grown in recent years, and low birth weight is the leading risk factor driving the increase, new research suggests. “If we can identify certain factors that put infants at risk for hemangiomas, that helps us understand how to prevent

Full Post: Low birth weight ups risk of infant skin tumors

By Will Dunham WASHINGTON (Reuters) - Babies conceived using in vitro fertilization are two to four times as likely to have certain birth defects than those conceived naturally, U.S. researchers said on Monday. In vitro babies are two to three times as likely to be born with cardiac defects involving a hole in the heart, according to

Full Post: Birth defect risk raised by in vitro fertilization

By Joene Hendry NEW YORK (Reuters Health) - Pregnant women with low levels of education are nearly twice as likely as their more educated peers to give birth prematurely, researchers from the Netherlands report. However, most of the risk can be attributed to the disadvantages that come with poor education, rather than educational level itself. In fact, as

Full Post: Education level linked to risk of preterm birth

Site Navigation

Most Read



  • kinwrite.com@gmail.com