Drug adherence poor in women with urinary trouble

NEW YORK (Reuters Health) - The odds are high that a woman who is prescribed an “anticholinergic” drug to relieve urinary incontinence or other lower urinary tract symptom will discontinue the medication not long after starting it, a study suggests. This is true regardless of the class of medication used.

Two examples of anticholinergic drugs that are often prescribed for urinary incontinence are oxybutynin (Ditropan) and tolterodine (Detrol).

“Our high discontinuation rates across all anticholinergic drug classes…highlight the need for more effective therapies for lower urinary tract symptoms,” Dr. Manish Gopal from Saint Peter’s University Hospital, New Brunswick, New Jersey and colleagues conclude.

Using a large database, Gopal and colleagues analyzed 29,369 women aged 18 and older who were initially prescribed an anticholinergic medication, such as Ditropan or Detrol, between 1991 and 2005.

They found that half of women prescribed an anticholinergic stopped taking it by 6 months, and 3 out of 4 women discontinued therapy by 1 year. The median time to discontinuation for all 9 different anticholinergic drugs was about 4 months after initial use.

In a report in the journal Obstetrics and Gynecology, the investigators note that rates of discontinuation increased with duration of use, and “very few women” switched to another drug after initial prescribed treatment before stopping the drug.

Because of the high discontinuation rates of anticholinergic therapy for lower urinary tract symptoms, health care providers “must be vigilant” regarding alternative forms of treatment, such as bladder training and pelvic floor rehabilitation, for overactive bladder “and increase our awareness that this group of women is being treated inadequately,” the investigators conclude.

SOURCE: Obstetrics and Gynecology, December 2008.


Related Posts:

NEW YORK (Reuters Health) - Ketamine, widely abused as a party drug and sometimes known as Special K, can cause inflammation and contraction of the bladder leading to possibly irreversible kidney damage, according to a report from Hong Kong. Ketamine is mostly used as a veterinary anesthetic. In humans, it causes hallucinations and high blood pressure.

Full Post: Ketamine abuse damages bladder, kidneys

By David Douglas NEW YORK (Reuters Health) - In children who continue to wet the bed despite standard treatment with desmopressin, adding the bladder-control drug tolterodine (Detrol) to therapy leads to a significant decrease in the risk of bedwetting, Missouri-based researchers have found. Desmopressin, lead researcher Dr. Paul F. Austin told Reuters Health, is the most frequently

Full Post: Drug combo may help curb bedwetting

Triamterene is a drug prescribed for the treatment of fluid retention in patients with liver cirrhosis, heart failure and nephrotic syndrome. The medicine has to be taken after food with full glass of water. Never take large amounts of Triamterene or take the drug for longer periods unless asked by your doctor. You should always maintain

Full Post: Triamterene is a drug prescribed for the treatment of fluid retention

NEW YORK (Reuters Health) - Among pregnant women at higher-than- average risk of premature delivery, those who are overweight or obese seem to be afforded some protection, a new study suggests. Researchers found that of 253 women who were followed during pregnancy, those who were overweight or obese had a far lower rate of preterm delivery

Full Post: Overweight women have lower risk of premature birth

Lexapro is an antidepressant medicine that is used for the treatment of depressions and mood changes. Belonging to a group of medicines called Selective Serotonin Reuptake Inhibitors, the drug works on the chemicals in the brain that causes the mood changes. Always keep a tab on the prescriptions and do not deviate from it. Never take

Full Post: Lexapro is used for the treatment of depressions and mood changes

Site Navigation

Most Read



  • kinwrite.com@gmail.com